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Medical Studies

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In your daily routine you need real facts that you can rely on. You are dealing with human health, after all. That is why we have developed a medical body composition analyzer that delivers precise results for the most important measurement parameters: the seca mBCA.

The accuracy was validated in a multicenter study with more than 250 subjects using only the best reference methods available to prove this. Such a complete and published study is rare. Normal ranges were generated by measuring more than 1000 patients for different genders, age-groups and ethnicities. The study is published and transparent for the public. The device even proved to accurately assess body compositions in extreme body compositions as found in hemodialysis subjects.

Study 1

Generation of a precise BIA equation in a multiethnic population

Prof. Dr. Gallagher

St. Luke's-Roosevelt Hospital
New York, USA

Prof. Dr. Dr. Bosy-Westphal

University Hohenheim
Kiel, Germany
Clinically validated data

The precision of the seca mBCA output parameters was validated across various ethnicities in a multicenter trial* using the respective most precise reference measurement method, also called the gold standard. This means you receive data that you can actually use and rely on.

Fat-free mass (FFM) was validated using the 4-compartment model (4C model). Only the 4C model takes into account the biological variability of the water and mineral content. Other methods such as DEXA can only partly estimate this, which can lead to less precision - particularly among thin and athletic patients. The fat-free mass (FFM) correlates to over 98% (R2 = 0.98) with the 4C model.


Fat-free mass measurement comparison between the seca mBCA and the 4C model

Total Body Water (TBW) In order to obtain a medically precise determination of body water it is necessary to make use of dilution methods that require time-consuming evaluation in the laboratory. The total body water (TBW) correlates to over 98% (R2 = 0.98) with deuterium dilution (D2O dilution) while the extracellular water (ECW) correlates to over 95% (R2 = 0.95) with the sodium bromide dilution (NaBr dilution).

Total body water measurement comparison between the seca mBCA and D2O dilution
Extracellular Water (ECW) measurement comparison between the seca mBCA and NaBr dilution

Muscle mass. Over 250 full-body MRI scans are evaluated in total. It is a time-intensive yet very thorough approach that cannot be achieved with things such as DEXA technology (which merely shows pixels in 2D). The result is that the muscle mass correlates to over 97% (R2 = 0.97) with magnetic resonance imaging (MRI).


Muscle mass measurement comparison between seca mBCA and MRI.

Study 1:
(BIA)Generation of prediction equations to analyze body composition of adults based on Boelectrical Impedance Analysis (BIA). Application and adaption of device specific body composition formulas to various ethnic groups.

Bosy-Westphal A, Schautz B, Later W. Kehayias JJ, Gallagher D, Müller MJ. What makes a BIA equation unique? Validity of eight-electrode multifrequency BIA to estimate body Composition in a healthy adult population. Eur J Clin Nutr 2013; 67: 14-21; doi:10.1038/ejcn.2012.160

Study 2

Generation of normal ranges for body composition analysis

Dr. Sven Peine

University Medical Center Eppendorf
Hamburg, Germany

The definition of cut-off values for all mBCA parameters was conducted in a study with more than 1.000 subjects, equally split in different gender, age, and BMI classes. The outcomes of this study results in statistically relevant normal ranges for all measuring results, which are available in easy-to-understand graphics.

Study 2:
Generation of normal ranges to analyze body composition of adults based on Bioelectrical Impedance Analysis (BIA)

S Peine, S Knabe, I Carrero, M Brundert, J Wilhelm, A Ewert, U Denzer, B Jensen and P Lilburn; Generation of normal ranges for measures of body composition in adults based on bioelectrical impedance analysis using the seca mBCA; International Journal of Body Composition Research 2013 Vol. 11 No. 3 & 4: 67-76

Study 3

Measuring body water in patients with fluid overloads

Prof. Dr. Hans-H. Neumayer

Charité University Medicine Berlin
Berlin, Germany

Dr. Torsten Slowinski

Charité University Medicine Berlin
Berlin, Germany

Dr. Kristina Norman

Department of Gastroenterology, Infectiology and Rheumatology (incl. section Nutritional Medicine), Charité University Medicine Berlin
Berlin, Germany

The seca mBCA does not only accurately assess body fluids in healthy subjects, but also in patients with critical fluid overloads. This was proven by measuring hemodialysis patients before and after dialysis and comparing the body water results to gold standard dilution methods.

Study 3:
Detection of patients with abnormal water distribution based on Bioelectrical Impedance Analysis (BIA)

Slowinski T, Lieker l, Otto B et al. Pilot study on the accuracy of bioimpedance analysis in detection of changes of body fluid composition in patients during a hemodialysis session. Abstract, 4. Jahrestagung der Deutschen Gesellschaft für Nephrologie 2012.